Status:
COMPLETED
240 mL Water Drink Study
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
University of Michigan
Conditions:
Healthy
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The GI MRI Research group at the University of Nottingham has been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the gastrointestinal tract. The investigators now w...
Detailed Description
Solid oral delivery is the most frequently used route of administration for pharmaceutical drug products. Along with other important physiological parameters, the volume of liquid in the small intesti...
Eligibility Criteria
Inclusion
- Apparently healthy; no medical conditions that might affect the study measurements
- Male or female
- Age between 18 and 55 years of age
- Body mass index (BMI) between 18.5 and 24.9 kg m-2
- Suitable for MRI scanning (eg absence of metal implants, infusion pumps and pacemakers as assessed by the MRI safety questionnaire
Exclusion
- Previous gastrointestinal surgery (excluding cholecystectomy and appendectomy)
- Known gastrointestinal disease
- Smoking
- History of alcohol or drug abuse
- Taking medication that is likely to affect gastrointestinal function
- Participation in night shift work the week prior to the study day. (Night work is defined as working between midnight and 6 am)
- Strenuous exercise greater than 10 hours per week
- Consumption of more than 21 units of alcohol in a typical week
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01792453
Start Date
February 1 2013
End Date
May 1 2013
Last Update
July 4 2013
Active Locations (1)
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1
University of Nottingham
Nottingham, Nottingham, United Kingdom, NG7 2RD