Status:
COMPLETED
Drug Monitoring of Antibiotics in Critical Care Patients
Lead Sponsor:
Ludwig-Maximilians - University of Munich
Conditions:
ARDS
Sepsis
Eligibility:
All Genders
18+ years
Brief Summary
Infections are critical factors for the survival of critically ill patients. A broad, high-dose and early initial therapy of antibiotics is of particular relevance. A serious problem is the high vari...
Detailed Description
Substantial variations of serum concentrations of different antibiotics with partly insufficient levels have been observed in critically ill patients. The high variabilities between the pharmacokineti...
Eligibility Criteria
Inclusion
- Hospitalisation in the critical care unit of the Department of Anaesthesiology of the University Hospital of Munich
- Presence of infection by clinical assessment
- Treatment of the patients with one or more of the following antibiotics: piperacillin/tazobactam, cefepime, meropenem, ciprofloxacin, linezolid, colistin
- Bolus administration of selected antibiotics
- Valid informed consent subscribed by the patient or by his or her legal guardian or - if only a provisional guardian is defined - by the provisional guardian.
Exclusion
- Prophylactic antibiotics without clinical assessment for the presence of infection
- Planned shorter hospital stay than 4 days
- Administration of the selected antibiotic 14 days to 48 hours before the begin of the study
- Only a single dose of an antibiotic per day
- Subsequent withdrawal of the participation in the study by the patient or the guardian
Key Trial Info
Start Date :
March 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
186 Patients enrolled
Trial Details
Trial ID
NCT01793012
Start Date
March 1 2013
End Date
January 1 2015
Last Update
September 2 2020
Active Locations (1)
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1
Department of Anaesthesiology of the University Hospital of Munich
Munich, Germany, 81377