Status:
COMPLETED
Cognitive Rehabilitation in Sickle Cell Disease
Lead Sponsor:
Duke University
Conditions:
Sickle Cell Disease
Cognitive Impairment
Eligibility:
All Genders
8-16 years
Phase:
NA
Brief Summary
The majority of school-age children with sickle cell disease (SCD) experience neurocognitive deficits, even in the absence of stroke. In particular, deficits in attention and working memory have emerg...
Eligibility Criteria
Inclusion
- 1\) Children with a diagnosis of SCD (all genotypes)
- 2\) a T-score ≥75th percentile on either the Metacognition or Executive Composite of the BRIEF; and/or
- 3\) a standard score ≥1 standard deviation below the mean (\<90) on the tasks of executive function or WM from the Cogstate (mean=100; SD=10)
Exclusion
- 1\) Estimated IQ ≤ 75), or motor, visual, or auditory handicap that prevents computer use;
- 2\) a diagnosis of depression or a pervasive developmental disorder (by history);
- 3\) clinical stroke (via record medical history); or
- 4\) non-English fluency.
Key Trial Info
Start Date :
October 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01793740
Start Date
October 1 2012
End Date
July 1 2014
Last Update
August 20 2014
Active Locations (1)
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1
Duke Child and Family Study Center
Durham, North Carolina, United States, 27705