Status:
COMPLETED
Role of Mesocorticolimbic Pathway in Apathy of Patients With Parkinson's Disease. - Study Using Diffusion Tensor Imaging and Fibres Tracking
Lead Sponsor:
University Hospital, Clermont-Ferrand
Conditions:
Parkinson's Disease
Apathy
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Use lay language. Apathy is one of the most under recognised, underdiagnosed and poorly managed aspects of Parkinson's disease. Depending on methodological approach of the study, its prevalence is es...
Detailed Description
3 groups : * 20 apathetic patients with Parkinson's disease * 20 non apathetic paired patients) * 20 healthy paired control Description of the protocol for patients : J0 : Inclusion visit (duration...
Eligibility Criteria
Inclusion
- \-
- Patients :
- Men or women aged between 18 -85 years
- Patients with an idiopathic Parkinson's disease according to UKPDSBB criterias
- Non dement (MMS ≥ 26 ; MATTIS ≥ 130)
- Affiliated to National Health system
- Having given their informed consent
- Healthy controls
- Men or women aged between 18 -85 years
- Affiliated to National Health system
- Having given their informed consent
Exclusion
- Patients :
- Patients suffering of an atypical Parkinson syndrome
- Psychiatric pathology
- Severe tremor form of PD
- Depression (MADRS \>16)., dementia (MMS \< 26, MATTIS \< 130).
- Pregnant
- Under guardianship
- In excluding period for another study
- Any contra-indication to MRI
- Healthy subject
- Subject with neurological, psychiatric diseases
- Depression, dementia, apathy
- Pregnant
- Under guardianship
- In excluding period for another study
- Any contra-indication to MRI
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
63 Patients enrolled
Trial Details
Trial ID
NCT01794195
Start Date
February 1 2013
End Date
December 1 2013
Last Update
July 1 2014
Active Locations (1)
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1
CHU Clermont-Ferrand
Clermont-Ferrand, France, 63003