Status:
COMPLETED
Lipoprotein Apheresis in Refractory Angina Study
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
National Institute for Health Research, United Kingdom
Conditions:
Refractory Angina
Raised Lipoprotein(a)>50mg/dL or >500mg/L
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
The goal of this study is to determine the impact of apheresis on clinical parameters and symptoms of patients with refractory angina and raised Lp(a). The investigators will conduct a prospective, ra...
Detailed Description
Angina which is refractory to conventional medical therapy and revascularisation is challenging to manage. Lipoprotein(a) or Lp(a) is a genetically determined form of LDL-cholesterol, elevation of whi...
Eligibility Criteria
Inclusion
- Patients diagnosed with refractory angina for more than three months.
- Two or more episodes of angina per week.
- Previous history of myocardial infarction, coronary artery bypass graft (CABG) surgery,percutaneous coronary intervention (PCI) or any combination of the above.
- Prescribed optimal medical therapy.
- Hypercholesterolaemia with an elevated Lp(a) \> 50mg/dL and an LDL-cholesterol less than 4.0mmol/L despite optimal lipid lowering drug therapy.
Exclusion
- Patients with poor calibre veins for cannulation.
- Patients with any other chronic systemic illness such as liver or renal failure, neoplastic disease, overt cardiac failure, unstable coronary artery disease, coronary revascularisation or a myocardial infarction within the previous eight weeks.
- Pregnancy, untreated diabetes mellitus, untreated arterial hypertension, and those with general contraindications to undergoing Cardiovascular magnetic resonance imaging or contraindications to adenosine.
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01796912
Start Date
February 1 2013
End Date
November 1 2015
Last Update
November 12 2019
Active Locations (1)
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1
Royal Brompton and Harefield NHS Foundation Trust
London, United Kingdom