Status:
COMPLETED
Effects of Dry Eye Treatments on the Ocular Surface
Lead Sponsor:
Baylor College of Medicine
Conditions:
Keratoconjunctivitis Sicca
Dry Eye Syndrome
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to evaluate whether, in people with dry eye syndrome, over the counter artificial tears and the prescription eye drop, dexamethasone, change or effect the eyes response to...
Detailed Description
This study evaluated the effects of the corticosteroid dexamethasone on suppressing development of eye irritation, cornea epithelial disease and increased production of inflammatory mediators in subje...
Eligibility Criteria
Inclusion
- Signature on the written informed consent form
- Patient motivation and willingness to cooperate with the investigator by following the required medication regimen
- Patient willingness and ability to return for all visits during the study
- Rapid tear film break up time of seven seconds or less in at least one eye AND
- Both cornea fluorescein staining score 3 or greater and conjunctival lissamine green staining 3 or greater in at least one eye
- Ocular Surface Disease Index Symptom Severity score of twenty or greater
- Tear meniscus height less than or equal to 200um
- Intact corneal sensitivity
- Willingness to discontinue use of any current dry eye treatment (except artificial tears) for four weeks prior to enrollment, and during the course of the study
Exclusion
- Compromised cognitive ability which may be expected to interfere with study compliance
- Uncontrolled or poorly controlled diabetes or heart or pulmonary disease that could, in the judgment of the investigator, jeopardize subject safety or interfere with the interpretation of the results of the study
- Known hypersensitivity to any components of the artificial tears or dexamethasone eye drops
- Anticipated contact lens wear during the study
- History of corneal transplant
- Active ocular infection, uveitis or non-Keratoconjunctivitis sicca related inflammation
- History of cataract surgery within 3 months prior to enrollment
- History of pterygium removal within 6 months prior to enrollment
- Reduced corneal sensitivity
- Initiation, discontinuation or change in dosage of hormone replacement therapy, fish oil, evening primrose, flaxseed, or black current seed oil supplements, antihistamines, cholinergic agents, beta-blocking agents, tricyclic or selective serotonin reuptake inhibitors, antidepressants, phenothiazines, or topical or systemic acne rosacea medications in two months prior to enrollment, or anticipated change in dosage during course of study
- Topical ophthalmic medications within prior 4 weeks, or anticipated use of same during the study (except artificial tears)
- Occlusion of the lacrimal puncta either surgically or with temporary collagen punctal plugs within three months prior to study, or anticipated use of same during study
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01797822
Start Date
February 1 2013
End Date
December 1 2015
Last Update
February 5 2020
Active Locations (1)
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1
Baylor College of Medicine, Alkek Eye Center
Houston, Texas, United States, 77030