Status:
UNKNOWN
Accuracy of TCD Monitoring in Predicting Cerebral Hyperperfusion Syndrome After Carotid Endarterectomy
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Carotid Stenosis
Cerebral Hyperperfusion Syndrome
Eligibility:
All Genders
30-85 years
Brief Summary
Background: Cerebral hyperperfusion syndrome (CHS) is a life threatening complication of carotid endarterectomy (CEA) and the changes of middle cerebral artery velocity are used to predict the occurre...
Detailed Description
This study is designed as a standard diagnostic test. It is designed to verify the predictive power of VSI with CHS, and which is an observational analytic clinical study. The investigative parameters...
Eligibility Criteria
Inclusion
- Age from 30 to 85 years;
- Had a middle-grade symptomatic carotid stenosis (more than 50%) or a high-grade asymptomatic carotid stenosis (more than 70%);
- Underwent CEA 30 days after the last ischemic cerebrovascular event in the case of symptomatic carotid stenosis;
- Signed the ethical information consent form
- Underwent TCD study intraoperative and immediately after CEA;
- The degree of carotid stenosis will be assessed by CT angiography or cerebral digital subtraction angiography (DSA). (The method document came from the North American Symptomatic Carotid Endarterectomy Trial study.)
Exclusion
- Emergency CEA within 30 days of stroke onset in the case of symptomatic carotid stenosis;
- No temporal windows to measure the MCAV.
- Restenosis after CEA or CAS
- Stenosis caused by non-atherosclerotic diseases
- Combined severe systematic diseases that markedly decrease the life cycle
- Allergy to medicines of the study such as Aspirin or Statin
- Refuse to sign the ethical information consent form
Key Trial Info
Start Date :
March 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2014
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT01799070
Start Date
March 1 2013
End Date
December 1 2014
Last Update
February 26 2013
Active Locations (1)
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1
vascular surgery department of PUMCH
Beijing, Beijing Municipality, China, 100730