Status:
COMPLETED
Evaluating Sensations of Breathlessness in Patients With Cystic Fibrosis
Lead Sponsor:
University of British Columbia
Conditions:
Lung; Disease
Cystic Fibrosis
Eligibility:
All Genders
19-50 years
Brief Summary
Shortness of breath (dyspnea) during exercise is a major source of distress and is a commonly reported symptom in patients with cystic fibrosis (CF). Due to the investigators' poor understanding of ho...
Detailed Description
The purpose of this study is to determine if sensations of breathlessness (dyspnea) are qualitatively and quantitatively different in patients with cystic fibrosis (CF) compared to age and sex-matched...
Eligibility Criteria
Inclusion
- CF patients (confirmed based on abnormal sweat chloride testing and/or CF Transmembrane Conductance Regulator (CFTR) genotyping)
- Between the ages of 19 to 50 (inclusive)
- Stable clinical status (CF: no changes in therapy in the past 4 weeks)
- Forced Expiratory Volume in 1 second (FEV1.0) \>40% predicted
- Body mass index greater than 18 or less than 30
- Currently non-smoking or a past smoking history of less than 20 pack-years
- Able to read and understand English
Exclusion
- A disease other than CF that could contribute to dyspnea or exercise limitation
- Having either of the chronic infections Mycobacterium abscessus or Burkholderia cepacia complex
- Contraindications to clinical exercise testing
- Use of supplemental oxygen or desaturation less than 85% with exercise
- Diagnosis of pneumothorax in the past 4 weeks
Key Trial Info
Start Date :
June 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01799642
Start Date
June 1 2013
End Date
December 1 2014
Last Update
November 20 2015
Active Locations (1)
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1
UBC James Hogg Research Centre, St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z1Y6