Status:
RECRUITING
Natural History Study of Synucleinopathies
Lead Sponsor:
NYU Langone Health
Conditions:
Patients With Synucleinopathies
Neurogenic Orthostatic Hypotension
Eligibility:
All Genders
18+ years
Brief Summary
Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and the abnormal accumulation of the protein α-synuclein in the nervous system. Onset is usually in late ...
Detailed Description
α-synuclein is a small protein of 140 amino acids that is highly expressed in the brain. It's function remains poorly understood.10 Synucleinopathies are a group of neurodegenerative diseases associat...
Eligibility Criteria
Inclusion
- Both male and female patients will be included
- Aged 18 or over
- Referred to any of the participating consortium sites with orthostatic intolerance, defined as symptoms of dizziness or lightheadedness in the standing position that disappear when supine.
Exclusion
- Diabetes according to the American Diabetes Association criteria
- Congestive heart failure
- Lupus or other collagen vascular disease
- Systemic illness thought to be responsible for the orthostatic intolerance
- Drug-induced orthostatic hypotension (i.e., the use of alpha-blockers, diuretics, tricyclic antidepressants or others thought by the investigator to play an important role in the patient's orthostatic hypotension)
- Isolated vasovagal syncope
- Inability to comply with the protocol, e.g. uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study.
Key Trial Info
Start Date :
June 1 2011
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2026
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT01799915
Start Date
June 1 2011
End Date
December 30 2026
Last Update
June 11 2025
Active Locations (8)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
2
University of Michigan
Ann Arbor, Michigan, United States
3
Mayo Clinic
Rochester, Minnesota, United States
4
NYU Medical Center
New York, New York, United States, 10016