Status:
COMPLETED
Characterization of LV Strain Patterns in Mildly Elevated PCWP and PAH.
Lead Sponsor:
University of Arizona
Conditions:
Hypertension, Pulmonary Artery
Ventricular Dysfunction, Left
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if patients with pulmonary hypertension and mildly elevated heart pressure known as PCWP will exhibit different patterns on echocardiography and that these pa...
Eligibility Criteria
Inclusion
- Patients with New York Heart Association/World Health Organization(NYHA/WHO)functional class II-III
- Patients with mean pulmonary artery pressure \>25 mmHg, pulmonary capillary wedge pressure \>15 mmHg ≤18, and pulmonary vascular resistance \>3 wood units
- Age \>18 and \<80
- Stable on antihypertensives and diuretics\>3 months
- No evidence of active ischemic heart disease
- 6 minute walk distance \>150 meters and \<450 meters
Exclusion
- \- Left ventricular ejection fraction \<50%
- Patients with significant restrictive lung disease (FVC\<60% predicted) and/or significant obstructive lung disease (FEV1 \<55% predicted) within 1 year of enrollment
- Poorly interpretable grey scale echocardiographic images
- Contraindications to right heart catheterization
- Nitroglycerin therapy
- Moderate-severe aortic and mitral valve abnormality
- Contraindications to submaximal exercise testing
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT01800292
Start Date
February 1 2013
End Date
December 1 2014
Last Update
November 4 2015
Active Locations (1)
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1
University of Arizona Medical Center
Tucson, Arizona, United States, 85724