Status:
COMPLETED
Cerebral GABA and Fear Conditioning in PTSD
Lead Sponsor:
Isabelle Rosso
Collaborating Sponsors:
Mclean Hospital
Conditions:
Stress Disorders, Post-Traumatic
Eligibility:
All Genders
20-50 years
Brief Summary
Posttraumatic stress disorder (PTSD) is a common and debilitating neuropsychiatric disorder in which an acute fear response to a traumatic event does not abate. This failure to recover from trauma is ...
Eligibility Criteria
Inclusion
- 20-50 years of age
- right-handed
- DSM-IV diagnosis consistent with group assignment
- groups to be matched for age, sex, education, race/ethnicity
- ability to provide written informed consent
- groups to be matched on proportion of female subjects in follicular/luteal menstrual phases.
Exclusion
- Medical condition that would confound results
- history of seizures or head trauma with loss of consciousness
- exposure to psychotropic medications within 4 weeks of study (8 weeks for fluoxetine)
- metal implants, claustrophobia or other Magnetic Resonance Imaging (MRI) exclusions
- positive urine toxicology or human chorionic gonadotropin (HCG) status on scan day
- history of psychotic disorder, bipolar disorder, eating disorder, mental retardation, or pervasive developmental disorder; history of meeting full criteria for non-PTSD anxiety disorder.
- PTSD and trauma subjects will be matched in terms of comorbid depressive disorder, not to exceed 50%. Trauma-exposed subjects will have a history of trauma exposure and will not meet criteria for PTSD. Non-traumatized healthy subjects will have no history of Axis I psychiatric disorder and no trauma exposure.
Key Trial Info
Start Date :
February 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2022
Estimated Enrollment :
126 Patients enrolled
Trial Details
Trial ID
NCT01800383
Start Date
February 1 2013
End Date
December 1 2022
Last Update
April 4 2023
Active Locations (1)
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1
McLean Hospital
Belmont, Massachusetts, United States, 02478