Status:
COMPLETED
Utilization of Genomic Information to Augment Chemotherapy Decision-making for People With Incurable Malignancies
Lead Sponsor:
British Columbia Cancer Agency
Collaborating Sponsors:
BC Cancer Foundation
Conditions:
Advanced Incurable Cancers
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Most systemic therapies are chosen on the basis of large randomized clinical trials; however, tumour heterogeneity means that cancers with similar histological features may have substantially differen...
Detailed Description
It is clear that carcinogenesis is an immensely complex process and that even within a histologic cancer subtype - such as adenocarcinoma of the lung or breast - there is significant heterogeneity in ...
Eligibility Criteria
Inclusion
- Subjects must have histologically or cytologically confirmed diagnosis of cancer
- This cancer must be incurable, as defined by their treating oncologist (generally because of advanced stage).
- Subjects must agree to provide archival tissue and agree to undergo a study specific biopsy and blood test for genetic analysis. All subjects would have a biopsy and blood samples at progression if it could be done safely.
- ECOG PS 0 or 1.
- Age \> 18 years of age.
- Subject consent must be obtained according to the BCCA requirements.
- Subject must be accessible for treatment and follow-up. Subjects must be registered at the BCCA Vancouver site.
Exclusion
- Unable or unwilling to undergo tumour biopsy(s) and/or blood/skin samples for normal DNA.
- Significant medical condition that in the opinion of the treating oncologist renders the subject not suitable for participation.
Key Trial Info
Start Date :
June 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2015
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01802905
Start Date
June 1 2012
End Date
February 1 2015
Last Update
February 5 2015
Active Locations (1)
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1
BC Cancer Agency
Vancouver, British Columbia, Canada