Status:
UNKNOWN
Efficacy Study of Neridronate to Treat Painful Osteoarthritis of the Knee With Bone Marrow Lesions.
Lead Sponsor:
ASST Gaetano Pini-CTO
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to determine whether neridronate is effective in the treatment of pain related to bone marrow oedema in patients with osteoarthritis of the knee.
Eligibility Criteria
Inclusion
- Clinical diagnosis of knee Osteoarthritis (ACR criteria)
- Radiographic diagnosis of knee Osteoarthritis (Kellgren/Lawrence scale \>=2)
- \>4 weeks but \<3 months pain, reported as \>30 mm on a 100 mm VAS scale
- bone marrow oedema of the affected knee on magnetic resonance
Exclusion
- inflammatory arthritis
- aseptic osteonecrosis of the knee
- previous or current treatment with Bisphosphonates
- serum calcium or creatinine abnormalities
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2013
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01803360
Start Date
March 1 2013
End Date
September 1 2013
Last Update
March 14 2013
Active Locations (1)
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1
Istituto Ortopedico Gaetano Pini
Milan, MI, Italy, 20122