Status:
COMPLETED
Effect of Ticagrelor on Endothelial Function
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Coronary Artery Disease
Endothelial Function
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This study is to assess the function of blood vessels while being treated with different types of blood thinners to determine the effect of these medications on blood vessels.
Eligibility Criteria
Inclusion
- Age\>18 years old
- At least two cardiovascular risk factors
- Demonstrated endothelial dysfunction
- Evidence of coronary artery disease
Exclusion
- Second (II) or third (III) degree heart block without a pacemaker
- Known active pathological bleeding, history of stroke, or bleeding diathesis
- Dyspnea classified as NYHA class III-IV
- Need for oral anticoagulants
- Clinically significant valvular heart disease
- Any concurrent life threatening condition with a life expectancy less than 1 year
- History or evidence of drug or alcohol abuse within the last 12 months
- Any surgical or medical condition, which in the opinion of the investigator, may place the patient at higher risk from his/her participation in the study, or is likely to prevent the patient from complying with the requirements of the study or completing the study
- History of hypersensitivity to any of the study drugs or to medications belonging to the same therapeutic class as the study drugs as well as known or suspected contraindications to the study drugs.
- Latex allergy
- History of noncompliance to medical regimens or unwillingness to comply with the study protocol
- Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer Positive pregnancy test, breast feeding women or women of child bearing potential not using highly effective methods of contraception.
- Patients who are also taking strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, nefazodone, ritonavir, and atazanavir)
- patients taking antiplatelet medications which cannot be stopped
- severe liver disease
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2016
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT01805596
Start Date
April 1 2013
End Date
July 1 2016
Last Update
October 5 2016
Active Locations (1)
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1
London Health Sciences Centre
London, Ontario, Canada, N6A5A5