Status:
TERMINATED
Surviving Aneurysm Surgery: A Pilot Study on Exercise Training in Abdominal Aortic Aneurysm Patients
Lead Sponsor:
Manchester University NHS Foundation Trust
Collaborating Sponsors:
University of Manchester
Conditions:
Abdominal Aortic Aneurysm
Aortic Disease
Eligibility:
All Genders
50-85 years
Phase:
NA
Brief Summary
An abdominal aortic aneurysm (AAA) is an enlargement or ballooning of the main artery supplying high pressure blood from the heart to the body. AAAs may continue to stretch until they burst (rupture) ...
Detailed Description
Abdominal aortic aneurysm (AAA) affects 4% of men aged 65-79, a prevalence rising as our population ages. As most patients suffering rupture die immediately, elective AAA repair is critical and the Na...
Eligibility Criteria
Inclusion
- Men or women with an AAA ≥3.5cm to \<5.5cm in men and ≥3.5cm to \<5.0cm in women
- Age 50-85 years and willing to consider exercise training
- Fit for either open or Endovascular Aneurysm Repair AAA repair
Exclusion
- Unable to participate in an exercise test or inability to exercise consistently because of musculoskeletal or other health problems
- History of severe liver disease (INR\>2, serum albumin \<3.0g/dL, jaundice)
- Unstable angina: Patients with angina of less than 2 months' duration, severe or occurring three or more times per day, or angina that is becoming either more frequent of precipitated by less exertion or angina at rest
- Uncontrolled atrial fibrillation (AF) or other arrhythmia: Untreated episodes of paroxysmal AF in the last 3 months
- Moderate or severe aortic valve stenosis (peak systolic pressure gradient \> 40mmHg and with an aortic valve area of \<1cm\^2.
- Class III/IV heart failure and / or an ejection fraction \<25%
- Active pericarditis or myocarditis
- CPET induced ischaemia
- Diagnosis or treatment for a malignancy (excluding skin) over the previous 12 months
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01805973
Start Date
June 1 2013
End Date
May 1 2014
Last Update
May 26 2020
Active Locations (1)
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1
University Hospital of South Manchester NHS Foundation Trust
Manchester, Lancashire, United Kingdom, M23 9LT