Status:
COMPLETED
Impact of a Short-Term High Fat or Low Fat Diet on Intestinal Genes Expression Involved in the Cholesterol and Fatty Acid Metabolism
Lead Sponsor:
Laval University
Conditions:
Gene Expression
Eligibility:
MALE
18-50 years
Phase:
NA
Brief Summary
Dietary fat has been shown to modulate cholesterol and fatty acids homeostasis and several lines of evidence suggest that this effect is associated with changes in the regulation of different genes at...
Eligibility Criteria
Inclusion
- Males 18 to 50 years of age
- Non-smoker
- Body mass index between 20.0 and 30.0 kg/m2
- Plasma LDL-cholesterol levels between the 25th and 75th percentile for their age at day -14
- Plasma triglyceride levels \< 1.7 mmol/L (150 mg/dl) at day -14
- Plasma HDL-cholesterol levels between 0.9 (35 mg/dl) and 1.6 mmol/L (60 mg/dl) at day -14
- Subjects must be willing to give written informed consent and able to adhere to the diet schedule and visit schedule
- Patients should be otherwise healthy, without elevations in hepatic transaminases or creatine kinase (CK) or abnormal renal function or coagulation
Exclusion
- Patients with extreme dyslipidemias, such as familial hypercholesterolemia will be excluded
- Subjects will be excluded if they have cardiovascular disease (CHD, cerebrovascular disease or peripheral arterial disease) or if they are taking other medications known to affect lipoprotein metabolism (eg. steroids, beta blockers, thiazide diuretics, other lipid lowering agents, significant alcohol intake etc.)
Key Trial Info
Start Date :
February 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2010
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01806441
Start Date
February 1 2009
End Date
December 1 2010
Last Update
March 7 2013
Active Locations (1)
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1
Institute of nutrition and functional food
Québec, Quebec, Canada, G1V 0A6