Status:
TERMINATED
Validation of a Dynamic Evaluation Tool in Respiratory Failure
Lead Sponsor:
Centre d'Investigation Clinique et Technologique 805
Collaborating Sponsors:
Adep Assistance
Conditions:
Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Determing optimal time of ventilator disconnection is a challenge for both acute and chronic neuromuscular disease. In one case it is helpful for weanning from ventilator and in the other to optimize ...
Detailed Description
Context: Mechanical ventilation transformed the prognosis of neuromuscular diseases whether for acute or chronic diseases. The available tools to estimate the severity of respiratory insufficiency an...
Eligibility Criteria
Inclusion
- Healthy volonteers Man or woman of more than 18 years Realization of a preliminary medical examination Patient having signed an informed and written consent Major healthy subjects, presenting no chronic pathology or not chronic patients
- Chronic patients Man or woman of more than 18 years Affected by neuromuscular pathology Realization of a preliminary medical examination Patient in the stable state at the time of the study for at least 1 month Ventilated in a not invasive or invasive way in diurnal and night-period. Respiratory autonomy \> 1:00 am Patient having signed an informed and written consent
- Acute Patients Man or woman of more than 18 years Affected by syndrome of Guillain blocked in aigue phase having required the invasive ventilation or affected by myasthenia generalized with myasthénique crisis having required the invasive ventilation.
- Realization of a preliminary medical examination Patient in phase of neurological recovery Vital Capacity \> 15 ml / kg Respiratory Autonomy \> 1:00 am Patient having signed a lit(enlightened) and written consent
Exclusion
- Healthy volonteers subject refusing to participate in the study subject under guardianship or guardianship Pregnant or breast-feeding Woman
- Chronic patients Patient refusing to participate in the study Patient under guardianship or guardianship Pregnant or breast-feeding Woman Patients ventilated only at night Clinically significant bronchial Dimensions(Congestion) Required by oxygen therapy
- Acute patients Patient refusing to participate in the study Patient or subject under guardianship or guardianship Pregnant or breast-feeding Woman Clinically significant bronchial Dimensions(Congestion) Required by oxygen therapy FIO2 \> 40 % PEP \> 5 cms H2O State of shock
Key Trial Info
Start Date :
November 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT01807663
Start Date
November 1 2012
End Date
June 1 2014
Last Update
September 26 2014
Active Locations (1)
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1
Hopital Raymond Poincare
Garches, Île-de-France Region, France, 92380