Status:
COMPLETED
Neural Functioning of Feeding Centers in Obese Youth
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Obesity
Insulin Resistance
Eligibility:
All Genders
12-17 years
Brief Summary
To explore whether obese adolescents with insulin resistance and relative low leptin levels exhibit functional alterations of the neuronal circuits involved in the regulation of energy metabolism and ...
Detailed Description
Functional Magnetic Resonance Imaging (fMRI) provides a non-invasive method to assess the functional pathways affected by nutrient ingestion and therefore can help answer important questions regarding...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Obese adolescents
- Good general health,
- taking no medication on a chronic basis
- Age 12 to 17 yrs,
- in puberty (girls and boys: Tanner stage II - IV)
- Obese Insulin Resistant Adolescents
- (BMI\> 95th)
- (WBISI\<1.2 plus a low adiponectin \<6 ug/dl and
- high triglyceride levels \>130mg/dl)
- Obese Insulin Sensitive Adolescents
- (BMI\>95th)
- (WBISI \>3) plus high adiponectin \>8 ug/ml and
- triglyceride levels \> 80 mg/dl Girls who begin menstruating must have a negative pregnancy test during the study
- Eligibility criteria for healthy non-obese children and adolescents:
- Brother or sister with obesity
- Age 12 to 17 years
- Normal fasting glucose and lipids in the child, and
- normal OGTT
- No use of any medication known to affect glucose, lipid metabolism and inflammation
- No endocrinopathies
- No use of any antipsychotic medication
- BMI \>25th to \<75th ( Center for Disease Control (CDC) BMI Charts)
- Minimum weight of 90lbs (CDC Growth Charts)
- Exclusion Criteria
- Baseline creatinine \>1.0 mg
- Pregnancy
- Presence of endocrinopathies (e.g. Cushing syndrome)
- Cardiac or pulmonary or other significant chronic illness
- Adolescents with psychiatric disorder or with substance abuse determined via self-report.
- Use of anorexic agents No metal implants
Exclusion
Key Trial Info
Start Date :
July 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 1 2017
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT01808846
Start Date
July 1 2010
End Date
February 1 2017
Last Update
April 27 2017
Active Locations (1)
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1
Yale University
New Haven, Connecticut, United States, 06510