Status:
COMPLETED
Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study)
Lead Sponsor:
University Hospital, Rouen
Conditions:
Acquired Haemophilia
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
CREHA project is a study comparing steroid combined with cyclophosphamide versus steroid combined with rituximab in patients with acquired haemophilia. The study will test the hypothesis that steroid ...
Detailed Description
CREHA project is a multicenter, randomized, controlled efficacity and safety study comparing steroid combined with cyclophosphamide versus steroid combined with rituximab in patients with acquired hae...
Eligibility Criteria
Inclusion
- men or women
- women post-menpausal or with ongoing contraception
- 18 years old or more
- diagnosis of acquired hemophilia
- patient must be insured
- patient has provided written informed consent prior to enrolment
- patient compliant
Exclusion
- constitutional hemophilia
- chemotherapy
- ongoing treatment with prednisone \> 20mg further more 1 month
- ongoing treatment with prednisone \>0.7 mg/d further more 10 days
- thrombocytopenia
- leukopenia
- chronic disease
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 14 2021
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT01808911
Start Date
May 1 2012
End Date
January 14 2021
Last Update
October 6 2025
Active Locations (34)
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1
University Hospital Amiens
Amiens, France, 80054
2
Hospital of Béziers
Béziers, France, 34525
3
Hospital Jean Verdier
Bondy, France, 93140
4
Hospital Ambroise Paré
Boulogne-Billancourt, France, 92104