Status:
COMPLETED
Monthly Versus Biweekly Endoscopic Variceal Ligation for the Prevention of Esophageal Variceal Rebleeding
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Collaborating Sponsors:
Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
National Yang-Ming University, Kaohsiung, Taiwan, ROC
Conditions:
Variceal Bleeding, Endoscopic Variceal Ligation
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Endoscopic variceal ligation (EVL) has proved to be effective in the prevention of esophageal variceal rebleeding. However, the optimal interval of EVL remains unclear. Our previous studies demonstrat...
Detailed Description
Esophageal varices are the most important portosystemic collaterals owing to their rupture results in variceal hemorrhage, which is a devastating event of portal hypertension. Cirrhotic patients survi...
Eligibility Criteria
Inclusion
- active or recent hemorrhage from esophageal varices;
- portal hypertension caused by cirrhosis
Exclusion
- age \> 80 or \<20 years old
- association with hepatocellular carcinoma or other neoplasms;
- association with cerebral vascular accident, uremia, acute coronary syndrome or other severe illnesses;
- history of gastric variceal bleeding;
- a history of undergoing EIS, EVL, cyanoacrylate injection or prior use of beta blocker;
- a history of prior shunt operation or transjugular intrahepatic portosystemic stent shunt (TIPS);
- deep jaundice (serum bilirubin \> 10 mg/dL);
- encephalopathy equal to or greater than stage II;
- failure in control of index variceal bleeding;
- death within 48 h of admission; or
- refusal to participate in the trial.
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT01809535
Start Date
January 1 2009
End Date
October 1 2012
Last Update
March 12 2013
Active Locations (1)
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1
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan, 81362