Status:
COMPLETED
A Prospective Study of Outcome After Therapy for Acromegaly
Lead Sponsor:
Columbia University
Collaborating Sponsors:
Icahn School of Medicine at Mount Sinai
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Acromegaly
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to evaluate hormone values and other markers of disease activity in a cohort of patients with acromegaly at the time of diagnosis and then prospectively after surgical or ...
Detailed Description
Surgical removal of the pituitary tumor is the usual first form of treatment offered, but this is curative in only approximately 70% of patients. If not adequately treated, the disease can have signif...
Eligibility Criteria
Inclusion
- Acromegaly Subjects
- Adult males and females.
- Ages 18 and over.
- Presenting to the PI or one of the sub-investigators for evaluation of acromegaly.
- Must have a biochemical diagnosis of acromegaly consisting of an elevated serum insulin-like growth factor 1 (IGF-1) level. Supportive although not required for entry are an elevated growth hormone (GH) level and a failure of GH to suppress normally after oral glucose administration.
- Willingness to participate in this study's procedures.
Exclusion
- Subjects who are unwilling to comply with the procedures outlined in the study.
- Subjects who do not have the ability to fully comprehend the nature of the study, to follow instructions, and/or cooperate with study procedures
- Are unwilling to provide informed consent to participate in the study.
- Healthy Subjects
- Inclusion Criteria:
- Adult males and females.
- Ages 18 and over.
- Responding to ads for participation or by word of mount.
- No medical problems, no medications, stable weight for 3 months prior to study.
- Willingness to participate in this study's procedures.
Key Trial Info
Start Date :
September 1 2003
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2025
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT01809808
Start Date
September 1 2003
End Date
August 1 2025
Last Update
August 26 2025
Active Locations (1)
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1
Neuroendocrine Unit; Columbia University Medical Center, 180 Fort Washington Avenue 9-970
New York, New York, United States, 10032