Status:
WITHDRAWN
Impact of PAV Versus NAVA on Patient-Ventilator Synchrony and Respiratory Muscle Unloading
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether two modes of artificial (i.e. mechanical) ventilation have an impact on patient synchrony with the ventilator (breathing machine) and on the patient's...
Detailed Description
New, "intelligent" ventilator modes with more complex closed loops have been developed, some with a demonstrated clinical benefit. The modes of proportional assist ventilation (PAV) and neurally-adjus...
Eligibility Criteria
Inclusion
- Age 18 years or older
- Respiratory failure requiring mechanical ventilation
- Spontaneously breathing (able to generate flow/ pressure/ volume triggers on control modes of ventilation or on a mode of mechanically assisted spontaneous breathing)
- Requiring FiO2\< 60% and PEEP\< 10cm H2O to maintain oxygen saturations \>90%
Exclusion
- Pregnancy
- Inability to tolerate spontaneous breathing
- Gastro-esophageal pathology (including but not limited to recent gastric or esophageal surgery, history of varices, known anatomical gastric or esophageal defects such as strictures, hernias or fistulas)
- Agitation necessitating major sedative infusions
- Hemodynamic instability necessitating active adjustments in vasopressor therapy
- Coagulopathy
- New intracranial pathology (stroke, hemorrhage, meningitis, encephalitis)
- Paralyzed diaphragm
Key Trial Info
Start Date :
April 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01810510
Start Date
April 1 2010
End Date
September 1 2016
Last Update
November 7 2016
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114