Status:
COMPLETED
Sex-specific Association With Kidney Disease
Lead Sponsor:
University of Sao Paulo General Hospital
Conditions:
Diabetic Nephropathy
Eligibility:
All Genders
11+ years
Brief Summary
Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide-generating nicotinamide adenine dinucleotide phosphate-oxidase 2 (NOX2, encoded by the CYBB gene) and the an...
Detailed Description
In the present study, three cohorts of type 1 diabetic patients (one Brazilian and two French/Belgium cohorts) were studied for the association with diabetic nephropathy (DN) with a total of 1396 pati...
Eligibility Criteria
Inclusion
- Overt 10 years of Diabetes Mellitus (Brazilian cohort)
- Diagnostic of diabetes before the age of 35 years, with initial ketosis and requirement for permanent insulin treatment within 1 year of diagnosis and past or present diagnosis of diabetic retinopathy. (Genesis cohort).
- Diagnostic of diabetes before the age of 35 years and past or present diagnosis of severe diabetic retinopathy. (GENEDIAB cohort).
Exclusion
- Patients presenting autoimmune diseases, HIV or HCV infections (Brazilian cohort)
- Patients with glomerular filtration rate \< 60 mL min-1 1.73 m2 without diabetic retinopathy (Brazilian cohort)
- Terminal cancer and personal disability (GENEDIAB cohort).
Key Trial Info
Start Date :
May 1 1994
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2012
Estimated Enrollment :
1396 Patients enrolled
Trial Details
Trial ID
NCT01810822
Start Date
May 1 1994
End Date
October 1 2012
Last Update
March 14 2013
Active Locations (1)
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1
Faculty of Medicine from University of São Paulo
São Paulo, São Paulo, Brazil, 01246-000