Status:
UNKNOWN
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
Lead Sponsor:
University of South Alabama
Conditions:
Burns
Trauma
Eligibility:
All Genders
19-70 years
Phase:
NA
Brief Summary
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers. Study hypothesis: Increased plasm...
Detailed Description
Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. A norma...
Eligibility Criteria
Inclusion
- Burn injury must be less than 24 hours old at time of initial sampling
- Burn must be 2nd or 3rd degree and at least 10% TBSA
- ISS (injury severity score) \> 15
Exclusion
- Burn injury/trauma injury \> than 24hours old at time of initial sampling
- Burn \< 10% total body surface area.
- Evidence of active infection on admission in the burn subjects.
- \< 19 years of age and \> 70 years
Key Trial Info
Start Date :
September 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT01812941
Start Date
September 1 2011
End Date
December 1 2021
Last Update
May 28 2021
Active Locations (1)
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1
University of South Alabama Medical Center
Mobile, Alabama, United States, 36617