Status:
COMPLETED
Role of Neutrophil Activation
Lead Sponsor:
Washington University School of Medicine
Conditions:
Patients Requiring Endotracheal Intubation
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique. Specimen samples...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Ages 18 to 65
- American Society of Anesthesiologists Physical Status Classification (ASA) I and II
- Required to have endotracheal intubation
- Scheduled for short admission (\<23 hrs), or ambulatory orthopedic surgery (ankle, shoulder, or extremity surgery); general surgery (exploratory laparotomy, cholecystectomy, ventral or inguinal hernia repair); obstetric/gynecological surgery(total abdominal hysterectomy, bilateral salpingo-oophorectomy); urologic surgery (nephrectomy, prostatectomy), lumbar spine surgery( discectomy, one or two level lumbar fusion) procedures.
- Estimated duration of surgery 3 to 4 hours.
- Provide informed consent
- Exclusion Criteria
- Active pulmonary disease within 5 days prior to enrollment
- On immunosuppressive medications
- Previous tracheal surgery
- On azithromycin
- Diabetes
- Pregnancy
- Smoking history of less than 6 weeks prior to surgery
- Surgery or intubation within 5 days of surgery
- Planned surgical procedure involving neck or thoracic regions
- Active pulmonary disease
- Autoimmune disease (HIV, AIDS, Rheumatoid Arthritis
- Hepatitis
- Cancer
Exclusion
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2017
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT01815229
Start Date
March 1 2013
End Date
July 1 2017
Last Update
July 15 2019
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110