Status:
WITHDRAWN
Does Pulmonary Rehabilitation Improve Breathing of COPD Patients
Lead Sponsor:
University of British Columbia
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world-wide. Dyspnea (i.e., sensations of breathlessness) is the hallmark symptom of patients with this disease. Pulmon...
Detailed Description
The purpose of this study is to determine if 8 weeks of pulmonary rehabilitation can reduce neuromechanical uncoupling (a disparity between the effort/drive to breathe and the breathing response) in p...
Eligibility Criteria
Inclusion
- A physician diagnosis of moderate-to-severe COPD
- Stable clinical COPD status (no history of an acute exacerbation requiring antibiotics or prednisone in the past 4 weeks)
- Post-bronchodilator Forced Expiratory Volume in 1 second (FEV1.0) ≥ 30 - \< 80% predicted and FEV1.0/Forced Vital Capacity ratio \< 0.7
- Body mass index \> 18 or \< 35 kg/m2
- Able to read and understand English
Exclusion
- Concurrent participation in or recent completion (\<6 weeks) of pulmonary rehabilitation
- An ulcer or tumor in their esophagus, or a nasal septum deviation (as reported by the participant)
- Had recent nasopharyngeal surgery
- Have a cardiac pacemaker
- Allergies to latex and sensitivities to local anesthetics
- Uncontrolled hypertension
- Diagnosis of diabetes
- Previous physician diagnosis of cardiovascular disease including: angina, acute coronary syndrome, heart failure, cerebrovascular disease, thromboembolic disease, peripheral vascular disease
- Other chronic lung disease including: asthma, interstitial lung disease, or pulmonary hypertension
- Chronic hepatic disease, chronic renal disease, or other systemic inflammatory disease
- Use of chronic oral steroids
- Dementia or uncontrolled psychiatric illness
- A disease other than COPD that could contribute to dyspnea or exercise limitation
- Contraindications to clinical exercise testing
Key Trial Info
Start Date :
May 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01815970
Start Date
May 1 2018
End Date
December 1 2019
Last Update
January 17 2018
Active Locations (1)
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1
UBC James Hogg Research Centre, St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z1Y6