Status:
COMPLETED
Cardiac GSI Feasibility Study
Lead Sponsor:
University Hospital Plymouth NHS Trust
Conditions:
High Risk of Significant Coronary Artery Disease
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
The recently introduced Computed tomography (CT) scanner, Discovery CT750 HD (GE Healthcare, Milwaukee), incorporates a battery of innovations aimed at improving diagnostic image quality, evaluating p...
Eligibility Criteria
Inclusion
- Accuracy arm
- Patients \>50 years of age
- Suspected or known coronary artery disease referred for ICA
- Stress perfusion arm
- Patients \>50 years of age
- Suspected or established coronary artery disease referred for MPI-SPECT for assessment of inducible ischaemia
- Delayed enhancement arm
- Patients \>50 years of age
- Referred for CMR for assessment of myocardial viability/scar
Exclusion
- Accuracy arm
- Consent cannot be obtained
- Patient BMI \> 30 kg /m2
- NYHA class III or IV heart failure
- Chronic total occlusion of target epicardial coronary artery
- Urgent revascularisation required
- Allergy to iodinated contrast or previous contrast induced nephropathy
- Intolerance or contraindication to beta-blockers
- Uncontrolled heart rhythm disturbances
- 2nd or 3rd degree atrioventricular block
- Estimated glomerular filtration rate \<30ml/min within two weeks prior to procedure or chronic renal failure on dialysis
- Pregnancy
- Stress perfusion arm
- As above, plus:
- Asthma (any) or intolerance to adenosine
- Delayed enhancement arm
- \- As for Accuracy arm
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01816750
Start Date
April 1 2013
End Date
June 1 2016
Last Update
October 24 2016
Active Locations (1)
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1
Plymouth Hospitals NHS Trust
Plymouth, Devon, United Kingdom, PL6 8DH