Status:
COMPLETED
Co-receptor Tropism Determination of HIV-1 Subtype A Spread in the Russian Federation Using V3-based Genotyping Tools
Lead Sponsor:
Dmitry Kireev
Collaborating Sponsors:
Pfizer
Conditions:
HIV Infection
Eligibility:
All Genders
18+ years
Brief Summary
To date, all work related to the study of HIV tropism, was performed on HIV B and C subtypes. In the studied samples, HIV variants of subtype A were virtually absent. However, the existence has been s...
Detailed Description
This study is a multicenter, single-step; with estimation of the prevalence of R5, X4, and R5X4-tropic HIV variants in a population of HIV-infected Russians naïve to CCR5-antagonists antiretroviral (A...
Eligibility Criteria
Inclusion
- Patients with confirmed HIV infection
- Confirmation of informed consent provided in writing
- Russian Federation citizenship
- Age 18 years and older
- Absence of pregnancy at the time of obtaining of biological material
- Availability of data about the date of 1st positive immune blot test, date of diagnosis and formulation of the clinical diagnosis, the result of viral load analysis performed in the previous 3 months, measuring of CD4 cell count performed in the previous 3 months, information about the ongoing ARV therapy for patients receiving antiretroviral therapy
Exclusion
- Pregnancy at the time of obtaining of biological material
- Patients receiving cytotoxic agents due to chemotherapy of cancer
- Patients receiving immunomodulatory drugs
- Participation in clinical trials with experimental drugs
- Experience of using of CCR5-antagonists
- Any condition which in the opinion of the investigator may affect the evaluation of the study results
Key Trial Info
Start Date :
November 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2013
Estimated Enrollment :
943 Patients enrolled
Trial Details
Trial ID
NCT01823614
Start Date
November 1 2012
End Date
December 1 2013
Last Update
March 20 2014
Active Locations (1)
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1
Central Research Institute for Epidemiology
Moscow, Russia, 111123