Status:
COMPLETED
Experimental Human Rhinovirus Infection
Lead Sponsor:
Radboud University Medical Center
Conditions:
Common Cold
Eligibility:
All Genders
18-35 years
Phase:
PHASE1
Brief Summary
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time...
Detailed Description
The importance of the common cold derives primarily from its frequency and from its enormous socioeconomic impact. Human Rhinoviruses (HRVs) are the major cause of the common cold, being responsible f...
Eligibility Criteria
Inclusion
- Age ≥18 and ≤35 years of age
- Healthy
- Use of contraceptives (for female subjects only)
Exclusion
- Pregnancy or lactating
- Pre-existent lung disease, including asthma
- A history of allergic rhinitis with positive allergen skin tests
- Use of any medication
- Use of alcohol \> 5/day or \>20/wk
- Use of any drugs
- Current smoker or more than 5 pack-year history
- Frequently have nosebleeds
- Recent nasal or otologic surgery
- Febrile illness or a common cold within four weeks before the HRV challenge
- Currently participating in another clinical trial
- Use of antibiotics, norit, laxatives (up till 6 months prior to inclusion), cholestyramine, acid burn inhibitors or immune suppressive agents (up till 3 months prior to inclusion), and pre- and probiotics (up till 1 month prior to inclusion).
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01823640
Start Date
March 1 2013
End Date
June 1 2014
Last Update
October 15 2014
Active Locations (1)
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1
Radboud University Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6525 HB