Status:
COMPLETED
Predicting the Conversion From Mild Cognitive Impairment to Dementia
Lead Sponsor:
Dongzhimen Hospital, Beijing
Conditions:
Mild Cognitive Impairment
Alzheimer Disease
Eligibility:
All Genders
40-85 years
Brief Summary
Mild cognitive impairment (MCI) is believed to be the early stage of dementia. The investigators assume that some psychological and imaging risks may predict the conversion. In the current longitudina...
Detailed Description
MCI increases the risk of later developing dementia. About 10-15% of the amnestic form of mild cognitive impairment will progress to Alzheimer's disease in one year. But some people with MCI never get...
Eligibility Criteria
Inclusion
- complaint about cognitive decline compared to previous performance
- objective cognitive impairment in one or more cognitive domains for age
- preservation of independence in functional abilities
- Mini-Mental State Examination(MMSE) scores between 24 and 30
- a Clinical Dementia Rating(CDR) score of 0.5
Exclusion
- dementia
- patient with any following disease: Parkinson's disease, multiple system atrophy, normal pressure hydrocephalus, progressive supranuclear palsy, subarachnoid hemorrhage, brain neoplasms, Huntington disease, epilepsy
- depression(HAMD \>7) or psychosis
- uncontrolled severe medical conditions(i.e., acute heart failure, renal insufficiency)
- current treatment with benzodiazepines, antidepressants, antipsychotics, or other medications with significant psychotropic or central cholinergic effects
- abnormal thyroid, low vitamin B12 level or low folic acid level
- patient with visual and auditory disorders can't cooperate with neuropsychological assessment
- patient can't cooperate with following up
- informed consent is not obtained
Key Trial Info
Start Date :
September 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2014
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT01823666
Start Date
September 1 2012
End Date
September 1 2014
Last Update
August 23 2021
Active Locations (1)
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1
Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine
Beijing, Beijing Municipality, China, 100700