Status:
TERMINATED
Non-invasive and Invasive Assessment of Coronary Artery Disease
Lead Sponsor:
University Medical Center Groningen
Conditions:
Coronary Artery Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of the study is to assess the diagnostic accuracy of a combined use of non-invasive coronary angiography with multi-slice computed tomography (MSCT) and stress cardiac magnetic resonance (...
Eligibility Criteria
Inclusion
- Patients with stable angina pectoris with low to intermediate pre-test likelihood of CAD;
- no previous history of CAD;
- obstructive stenosis (≥50% luminal narrowing) on MSCT coronary angiography; 4.informed consent.
Exclusion
- patients with a previous history of CAD;
- patients with contraindications for MSCT: a.cardiac rhythms other than sinus rhythm, b.pregnancy, c.allergy for contrast medium, d.renal failure (estimated glomerular filtration rate (eGFR) \< 50ml/min), e.resting heart rate \>75 bpm plus contra-indications for beta-blockade, f. weight \>100 kilograms;
- contraindications for cardiac magnetic resonance (CMR) imaging: a.MR-incompatible implants, b. Claustrophobia, c. contraindications for adenosine: i. known or suspected hypersensitivity to adenosine, ii. known or suspected bronchoconstrictive or bronchospastic disease, iii. 2nd or 3rd degree atrioventricular (AV) block, iv. Sinus bradycardia (heart rate \< 45 bpm), v. Systemic arterial hypotension (\<90 mmHg). d. contraindications for gadolinium: i. renal failure (estimated eGFR \<30 ml/min);
- no informed consent.
Key Trial Info
Start Date :
November 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01823809
Start Date
November 1 2011
End Date
October 1 2016
Last Update
May 4 2018
Active Locations (2)
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1
University Medical Center Groningen, Departments of Cardiology and Radiology
Groningen, Netherlands, 9700 RB
2
University Hospital Linköping, Departments of Clinical Physiology, Cardiology and Center for Medial Imaging Visualization
Linköping, Sweden