Status:

COMPLETED

Muscle Protein Metabolism in Obesity

Lead Sponsor:

Mayo Clinic

Collaborating Sponsors:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Conditions:

Obesity

Eligibility:

All Genders

18-50 years

Phase:

PHASE1

Brief Summary

Obesity is associated with reduced adenosine triphosphate (ATP) turnover in skeletal muscle, a condition that can impair muscle metabolism. The proposed research will discover mechanisms responsible f...

Eligibility Criteria

Inclusion

  • Inclusion criteria:
  • Body mass index (BMI): lean, 19-26 kg/m2; obese, 30-40 kg/m2
  • Availability of transportation
  • Ability to sign informed consent form
  • Exclusion criteria:
  • Medication or supplements (i.e. amino acids, protein) known to affect protein metabolism
  • Presence of acute illness
  • History of liver disease
  • Uncontrolled metabolic disease
  • ECG documented abnormalities, atrial fibrillation, history of syncope, limiting or unstable angina, or congestive heart failure
  • Chronically elevated blood pressure (systolic, \>140 mmHg; diastolic, \>100 mmHg)
  • Cardiac pacemaker or other medical device implanted in the body
  • Low hemoglobin or hematocrit
  • Current participation in a weight-loss regimen, including extreme dietary practices
  • Smoking
  • Use of anabolic steroids or corticosteroids (within 3 months)

Exclusion

    Key Trial Info

    Start Date :

    October 1 2012

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ESTIMATED

    End Date :

    February 7 2020

    Estimated Enrollment :

    84 Patients enrolled

    Trial Details

    Trial ID

    NCT01824173

    Start Date

    October 1 2012

    End Date

    February 7 2020

    Last Update

    April 3 2020

    Active Locations (1)

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    1

    Mayo Clinic in Arizona

    Scottsdale, Arizona, United States, 85259