Status:
COMPLETED
Effect of Glucose-Insulin-Potassium on Hyperlactatemia in Patients Undergoing Valvular Heart Surgery
Lead Sponsor:
Yonsei University
Conditions:
Valvular Heart Disease
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Hyperlactatemia, occuring 10-20% in patients undergoing valvular heart surgery, is known to be associated with hemodynamic instability, organ dysfunction and increased postoperative morbidity and mort...
Eligibility Criteria
Inclusion
- patients(20 yr or older) undergoing elective valvular heart surgery under cardiopulmonary bypass(CPB) with more than 2 of following features:
- congestive heart failure
- infective endocarditis
- redo valvular surgery
- surgery combined with coronary bypass graft
- multiple valvular surgery
- expected CPB duration longer than 2 hr 7\> preoperative serum creatinine over 1.4 mg/dl 8\> preoperative hemoglobin level less than 12 mg/dl 9\> left ventricular ejection fraction less than 40%
Exclusion
- emergency surgery
- hemodynamic instability before surgery (mean arterial pressure \< 60 mmHg, heart rate \>100 /min
- need for pharmacological or mechanical assist for hemodynamic stability before surgery
- baseline blood lactate level more than 2 mmol/l
- on steroid or NSAID
- hepatic dysfunction
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
106 Patients enrolled
Trial Details
Trial ID
NCT01825720
Start Date
March 1 2013
End Date
May 1 2013
Last Update
October 11 2013
Active Locations (1)
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1
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute
Seoul, Seoul, South Korea, 120-752