Status:
COMPLETED
Hypertension and Urine Protease Activity in Preeclampsia
Lead Sponsor:
Odense University Hospital
Collaborating Sponsors:
The Danish Council for Strategic Research
Lundbeck Foundation
Conditions:
Preeclampsia
Hypertension
Eligibility:
FEMALE
18-45 years
Phase:
NA
Brief Summary
Preeclampsia (PE) is a common disorder of pregnancy that complicates 4-7% of all pregnancies. It is a serious condition with acute proteinuria and hypertension and varying degrees of edema after 20 we...
Detailed Description
Selection of patients: The selection of patients is based on outpatients with preeclampsia and patients with normal pregnancies recruited from gynecological-obstetric department, Aarhus University Ho...
Eligibility Criteria
Inclusion
- Cases:
- Pregnancy week 28-36 (exclusion of patients with previously severe preeclampsia).
- Singleton pregnancy
- Preeclampsia- hypertension: repetitive high blood pressures (\> 140/80 mm Hg) measured in the consultation and proteinuria (dip test, albumin).
- Pregnant with microalbuminuria and proteinuria, but without hypertension (and therefore do not meet the diagnostic criteria for preeclampsia) can also be included. Proteinuria is the most important factor.
- It is still possible to test our hypothesis with possible comorbidity such as diabetes, SLE(systemic lupus erythematosus), rheumatoid arthritis and therefore not a reason for exclusion.
Exclusion
- Hypertension in pregnancy without proteinuria.
- Pregestational nephropathy by other unknown reasons.
- Early severe preeclampsia.
- Organic or systemic disease of clinical relevance, such as malignancy.
- Pregnant controls-
- Inclusion Criteria:
- pregnancy week 28-36
- Singleton pregnancy
- Uncomplicated pregnancy
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT01828138
Start Date
May 1 2013
End Date
October 1 2015
Last Update
October 16 2015
Active Locations (1)
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1
Gynelogical Obstetrical Department
Skejby, Aarhus, Denmark, 8200