Status:
COMPLETED
Effects of CPAP on Visceral Fat Thickness
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
We hypothesize that patients with untreated OSAS will have more visceral fat, fatty liver and increased carotid artery thickness whereas treatment with CPAP may reduce the mesenteric and liver fat, pl...
Detailed Description
This proposed randomized control trial (RCT) will compare the effects of therapeutic CPAP versus subtherapeutic CPAP in patients newly diagnosed with OSA with reference to visceral fat especially mese...
Eligibility Criteria
Inclusion
- symptomatic patients with OSA of apnea hypopnea index (AHI) \>= 5/hr
Exclusion
- Recent or past history of myocardial infarction/stroke/heart failure, unstable angina, underlying malignancy,
- patients with clinical features of any active infection
- those who require urgent CPAP treatment because of associated respiratory failure or to prevent job loss through excessive daytime sleepiness (eg professional drivers, those handling dangerous machinery)
- moderate to severe valvular heart disease, cardiomyopathy, and previous diagnosis of OSA and/or previous use of CPAP therapy.
Key Trial Info
Start Date :
February 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
141 Patients enrolled
Trial Details
Trial ID
NCT01828281
Start Date
February 1 2012
End Date
August 1 2015
Last Update
November 16 2015
Active Locations (1)
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1
Respiratory Division
Hong Kong, China