Status:
COMPLETED
A Prospective Comparison of Methadone, Fentanyl, and Morphine for Post-laparotomy Epidural Analgesia
Lead Sponsor:
Hadassah Medical Organization
Conditions:
Post Laparotomy Pain Treatment
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
The current study aim is to compare between the opioids morphine, fentanyl and methadone in terms of efficacy and side effects profile when administered epidurally for pain management after laparotomi...
Eligibility Criteria
Inclusion
- \* Elective laparotomy
Exclusion
- Subjects with diabetes mellitus, other neurological or systemic disease associated with altered sensory perception
- Illicit drug abusers
- Chronic use of pain medication
- Inability to understand consent form
- Age \< 18
- Renal failure (Clcr\<50 ml/min)
- Chronic use of drugs that can alter plasma levels and\\or effect of the study drugs
- Corrected Q-T interval(QTc)=450msc and above
- Contra-indication for epidural catheter insertion
- Pregnancy
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2016
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01828840
Start Date
April 1 2014
End Date
December 1 2016
Last Update
March 22 2022
Active Locations (1)
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1
Hadassah Medical Organization
Jerusalem, Israel, 91120