Status:
COMPLETED
Brain Imaging of rTMS Treatment for Depression
Lead Sponsor:
Stanford University
Collaborating Sponsors:
The Dana Foundation
National Institute of Mental Health (NIMH)
Conditions:
Major Depressive Disorder
Depression
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
The overarching goal of this research program is to elucidate causal and directional neural network- level abnormalities in depression, and how they are modulated by an individually-tailored, circuit-...
Detailed Description
This study has a single primary outcome measure and other measures are exploratory. Previous versions of this study record incorrectly listed some exploratory outcome measures as secondary.
Eligibility Criteria
Inclusion
- Men and women, ages 18 to 50
- Depression assessed through phone screen
- Must comprehend English well to ensure adequate comprehension of the fMRI and TMS instructions, and of clinical scales
- Has failed \>1 previous adequate antidepressant medication trials
- Right-handed
- No current or history of neurological disorders
- No seizure disorder or risk of seizures
Exclusion
- Any contraindication to being scanned in the 3T scanners at the Lucas Center or CNI such as having a pacemaker or implanted device that has not been cleared for scanning at the Lucas Center or CNI
- Any unstable medical condition, any significant CNS neurological condition such as stroke, seizure, tumor, hemorrhage, multiple sclerosis, etc
- Current rTMS treatment or prior treatment failure with rTMS
- Current electroconvulsive therapy (ECT) or prior treatment failure with ECT
- Currently pregnant or breastfeeding
Key Trial Info
Start Date :
September 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 20 2017
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT01829165
Start Date
September 1 2012
End Date
January 20 2017
Last Update
April 10 2018
Active Locations (1)
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1
Stanford University
Palo Alto, California, United States, 94304