Status:
RECRUITING
Prediction of Outcome After Chemoradiotherapy for Head and Neck Cancer Using Functional Imaging and Tumor Biology
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Collaborating Sponsors:
Flemish League Against Cancer
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Despite uniform histopathological definition the response of locally advanced squamous cell carcinomas of the head and neck (HNSCC) to ionizing radiation differs greatly with locoregional recurrences ...
Detailed Description
1. BACKGROUND AND SETTING 1.1. Introduction Concurrent (chemo-) radiotherapy (CRT) is the current standard of care for patients with locally advanced head and neck squamous cell carcinoma (HNS...
Eligibility Criteria
Inclusion
- ≥ 18 years old
- Patients with non-metastatic locally advanced oropharyngeal cancer who will be treated with chemoradiotherapy, as decided after multidisciplinary consultation.
- A karnofsky performance status ≥ 70%
- Gender: Male - Female
- Informed consent obtained, signed and dated before specific protocol procedures
Exclusion
- Prior irradiation to the head and neck region
- Medical contraindications for any of the planned investigations
- Distant metastases
- Pregnant or lactating women
- Mental condition rendering the patient unable to understand the nature, scope, and possible consequences of the study
- Patient unlikely to comply with the protocol, i.e. uncooperative attitude, inability to return for follow-up visits, and unlikely to complete the study
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT01829646
Start Date
March 1 2013
End Date
March 1 2026
Last Update
March 31 2023
Active Locations (1)
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1
Departement of Radiation Oncology
Leuven, Belgium, 3000