Status:
COMPLETED
A Phase I Study of Hetrombopag Olamine in Healthy Adult Volunteers
Lead Sponsor:
Jiangsu HengRui Medicine Co., Ltd.
Conditions:
Healthy
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
Hetrombopag Olamine made by Jiangsu Hengrui Medicine co Ltd. has shown an effect of increasing platelet count in animal and human. This study is designed in dose escalation fashion to evaluate safety,...
Detailed Description
1. To evaluate safety and tolerability of Hetrombopag Olamine. 2. To investigate pharmacokinetics of Hetrombopag Olamine Under fasting conditions. 3. To obtain pharmacodynamics information of Hetrombo...
Eligibility Criteria
Inclusion
- Subject must be adequately informed of the nature and risks of the study, able to understand the risks associated with the study, and are willing to provide written informed consent prior to screening.
- Must be a healthy male between the ages of 18 to 45 years, inclusive.
- Must have a BMI between 19 to 28 kg/m2, inclusive and a total body weight ≥50 kg.
- Platelet counts must be within the normal range.
- Subjects must be free of any clinically significant disease based on medical history and physical examination.
- Clinical laboratory tests (complete blood count \[CBC\], blood chemistries, and urinalysis) must be within the normal limits or clinically acceptable.
- Must be nonsmokers, defined as not having smoked tobacco or used chewing tobacco or nicotine.
- Subjects of reproductive potential with partners who are women of childbearing potential, will be instructed to, and must be willing to practice a highly effective method of birth control for the duration of the study and continuing 6 months after discontinuing treatment with the investigational product.
Exclusion
- History of hypersensitivity to hetrombopag olamine or its components.
- History or presence of significant cardiovascular deficient, pulmonary, hepatic, gallbladder or biliary tract, renal, hematological, gastrointestinal, endocrine, immunological, dermatological, neurological, or psychiatric disease, or any other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs.
- History of deep vein thrombosis, or any other thromboembolic event.
- History or presence of conditions that may place the subject at increased risk as determined by the investigator.
- History of thrombocytopenia or bleeding due to abnormal platelet number or function.
- History of platelet clumping that prevents reliable measurement of platelet counts.
Key Trial Info
Start Date :
April 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2013
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT01830660
Start Date
April 1 2012
End Date
June 1 2013
Last Update
April 6 2015
Active Locations (1)
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1
West China Hospital, Sichuan University
Chengdu, Sichuan, China