Status:
COMPLETED
Purine Metabolism Enzyme SNP to Uric Acid Production
Lead Sponsor:
Keesler Air Force Base Medical Center
Collaborating Sponsors:
United States Air Force
Conditions:
Gout
Hyperuricemia
Eligibility:
All Genders
18+ years
Brief Summary
Determine whether a relationship exists between polymorphisms of the genes XDH, HPRT1, and PRPS1 and gout, hyperuricemia, or the dose of xanthine oxidase (XO) inhibitors to reach a goal serum uric aci...
Detailed Description
Background: Our recent gout study demonstrated a relationship between the xanthine oxidase (XO) single nucleotide polymorphism (SNP) 2107A\>G to the dose of allopurinol needed to reach a goal serum ur...
Eligibility Criteria
Inclusion
- The study will be open to all adults over age 18 years of age who satisfy at least one of the conditions below:
- Have asymptomatic hyperuricemia (serum uric acid level \> 7.0 mg/dL) on at least 2 separate occasions,
- Clinical diagnosis of gout,
- Have neither asymptomatic hyperuricemia or gout but will serve as part of the control group (approximate age/gender matched control)
Exclusion
- To best isolate the relationship between purine enzyme SNPs to hyperuricemia or gout and its treatment, factors which could elevate the serum uric acid level independent of protein function need to be excluded. Specifically, patients who are "overproducers" of serum uric acid will be excluded:
- Have a myeloproliferative disorder (hematologic malignancy such as leukemia or lymphoma)
- Are actively receiving therapy for any neoplasia (aside from non-melanoma skin cacner)
- Have greater than 5% of skin involvement from psoriasis
- Have a known history of xanthinuria
- Consume more than 14 drinks per week of alcoholic beverages
- Patients that are pregnant or nursing will not be enrolled. Patients to be enrolled in the control group will also be excluded from enrollment if they have any of the conditions above.
Key Trial Info
Start Date :
December 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01830725
Start Date
December 1 2012
End Date
June 1 2016
Last Update
August 30 2016
Active Locations (1)
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1
Keesler Medical Center
Keesler Air Force Base, Mississippi, United States, 39564