Status:
COMPLETED
Predicting Response to CRT Using Body Surface ECG Mapping
Lead Sponsor:
Tom Jackson
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
CardioInsight Technologies, Inc.
Conditions:
Heart Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiac resynchronization therapy (CRT) involves pacing the left and right side of the heart in order to improve the coordination of the contraction in patients with heart failure. Current selection c...
Eligibility Criteria
Inclusion
- Age \>18 years old
- Fulfils established clinical criteria for CRT implantation (with or without a defibrillator)
- NYHA Class III-IV Heart Failure (or NYHA II with NYHA III/IV symptoms in the preceding 12 months)
- LVEF \<35% (Calculated using echocardiography or Cardiac MR) at the time of implantation
- QRS duration \> 130ms
- Optimal Tolerated Medical Therapy for Heart Failure
Exclusion
- Severe, life threatening non cardiac disease
- Active malignant disease and recent (\<5 years) malignant disease
- Prior Heart Transplant
- Recent history of unstable angina, acute coronary syndrome or myocardial infarction within three months of enrolment into the study
- Pregnancy
- Failure to participate in consent process
- Atrial Fibrillation
- Conventional pacemaker in situ
- Heart Failure requiring constant intravenous therapy including diuretics and/or inotropes
- Recent revascularisation procedure i.e. coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within the last three months
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01831518
Start Date
July 1 2014
End Date
June 1 2016
Last Update
October 5 2018
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
2
The Royal Brompton and Harefield NHS Foundation Trust
London, United Kingdom, SW3 6NP