Status:
UNKNOWN
Effect of Fluvoxamine on Cognition, Behavior, Symptoms and mRNA and Protein Expression in Schizophrenia Patients
Lead Sponsor:
Sha'ar Menashe Mental Health Center
Conditions:
SCHIZOPHRENIA 1 (Disorder)
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine effect of Fluvoxamine augmentation on cognitive function , aggressive behavior , clinical symptoms and mRNA (messenger ribonucleic acid) and protein expressio...
Detailed Description
Clinical studies have shown that adding selective serotonin reuptake inhibitor (SSRI) antidepressants to antipsychotics can improve negative symptoms of schizophrenia in patients unresponsive to antip...
Eligibility Criteria
Inclusion
- Age 18-65
- A diagnosis of schizophrenia (DSM-IVTR)
- Antipsychotic dose unchanged for at least 2 weeks prior to study
- SANS score\>= 3 on at least one of the global measures of affective blunting, alogia or avolition.
- Knowledge of Hebrew
Exclusion
- Dementia or other serious neurological disorders
- History of alcohol or drug use
- Patients with a legal guardian
- Patients involuntarily hospitalized by order of the district psychiatrist
- Use of antidepressants within 1 month of the study
- Renal or hepatic disorder
- Patients with upper GI bleeds
- Patients with SIADH syndrome
- Pregnant woman
- Criteria for the cessation of the study after initial commencement
- Severe adverse events (including but not only GI, cardiovascular, neurologic, hematologic or urologic severe adverse events)
- Emergent suicidality
- Emergence of hypomanic or manic symptoms
- If the subject requests to stop
Key Trial Info
Start Date :
December 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2013
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT01832285
Start Date
December 1 2012
End Date
December 1 2013
Last Update
April 23 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Shaar Menashe Mental Health Center
Hadera, Ha Sharon, Israel, 38242