Status:
COMPLETED
Protein Profile of Immunoregulatory Factors in Diabetic Cataract
Lead Sponsor:
University of Zagreb
Conditions:
Cataract
Type 2 Diabetes Mellitus
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The purpose of this study is to compare the levels of several immunoregulatory factors in serums and aqueous humor of type II diabetes cataract patients with those in senile non-diabetic cataract pati...
Detailed Description
The study compared the levels of several immunoregulatory molecules (vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1), Fas Ligand (FasL), interleukin-10 (IL-10) and in...
Eligibility Criteria
Inclusion
- patients undergoing phacoemulsification combined with IOL implantation
- for diabetic group: duration of type 2 diabetes mellitus (T2DM) for 10 to 15 years
- for diabetic group: therapy with oral hypoglycemic agents for glycemic control
- no other ocular (retinal) or systemic diabetic complications of T2DM
Exclusion
- patients who had cataract that could result from some other ocular condition, systemic disease (except T2DM for diabetic group) or trauma
- patients with immune disease, local or systemic inflammation which could affect cytokine concentration in serum or aqueous humor (AH)
Key Trial Info
Start Date :
January 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2012
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT01832311
Start Date
January 1 2009
End Date
December 1 2012
Last Update
April 16 2013
Active Locations (2)
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1
Department of Ophtalmology, General Hospital "Dr. J. Bencevic"
Slavonski Brod, Brod-Posavina County, Croatia, 35000
2
Department of Physiology and Immunology, University of Zagreb School of Medicine
Zagreb, City of Zagreb, Croatia, 10000