Status:
COMPLETED
Using MRI to Observe Lung Changes in Infants With CF Compared to Infants Without CF
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Cystic Fibrosis
Eligibility:
All Genders
6-52 years
Brief Summary
Our research is comparing the lungs of babies and young children with CF (cystic fibrosis) to those without CF. We are looking at the blood flow in the lungs to help doctors better understand how CF d...
Detailed Description
Cystic fibrosis (CF) is a well characterized multi-organ disease producing mucus obstruction, chronic lung infection, inflammation, and oxidant stress. These processes result in airway damage, chronic...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- CF
- Age at enrollment 6 to 12 months or 24 to 52 months.
- Diagnosed with two CF-causing mutations ('severe' mutations, classes 1, 2, or 3).
- Non-CF
- Age at enrollment 6 months to 52 months
- Clinically scheduled for MRI neuroimaging
- Negative history of renal abnormalities
- Exclusion criteria:
- CF
- Pulmonary exacerbation
- Any known intracardiac defects
- Serum creatinine \> 1.5 times the upper limit of normal for age
- Cystatin C \> 0.53 (cutoff for normal range)
- Non-CF
- Active lung disease as determined by assessment of anesthesiologist
- Any known intracardiac defects
- Results of the most recent serum creatinine within past 12 months above normal range for age
Exclusion
Key Trial Info
Start Date :
February 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 9 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT01832519
Start Date
February 1 2013
End Date
January 9 2017
Last Update
August 23 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229