Status:
COMPLETED
Brain Dynamics of Oxytocin
Lead Sponsor:
Stony Brook University
Collaborating Sponsors:
Martinos Center for Biomedical Imaging
Conditions:
Brain Dynamics in Healthy Adults
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
Brief Summary
Oxytocin is a neuropeptide that is well known for its role in social and affiliative behavior in humans. Oxytocin receptors are significantly lowered in autistic individuals and administration of oxyt...
Detailed Description
The purpose of the study is to understand how oxytocin affects brain and behavior. The study will compare Syntocinon Nasal Spray to placebo. The specific aims are to: 1. Determine the default circuit...
Eligibility Criteria
Inclusion
- 18-45 years of age
Exclusion
- any significant known medical condition, including mental disorders (confounds interpretation of brain activity)
- metal in the body or claustrophobia (contraindicated for fMRI)
- current use of any type of psychotropic medication (confounds interpretation of brain activity)
- body mass index of greater than 30 (to permit matched dosing across subjects)
- pregnancy (contraindicated for OT)
- breastfeeding (lactation endogenously triggers OT, which would not permit a placebo condition)
- smoking (affects use of nasal spray)
- use of drugs of abuse (confounds interpretation of brain activity)
- blood pressure above the normal range (140/90 mm Hg) or controlled with medication (may theoretically increase risk for OT side-effects)
- anosmia (affects use of nasal spray)
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT01834261
Start Date
April 1 2013
End Date
May 1 2015
Last Update
March 17 2017
Active Locations (3)
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1
Martinos Imaging Center at the McGovern Institute for Brain Research at MIT
Cambridge, Massachusetts, United States, 02139
2
Martinos Center for Biomedical Research, Building 149, 13th Street
Charlestown, Massachusetts, United States, 02129
3
Bioengineering Building , Stony Brook University
Stony Brook, New York, United States, 11794