Status:
COMPLETED
Translational Research Evaluating Neurocognitive Memory Processes
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Neurocognition
Eligibility:
All Genders
18-85 years
Brief Summary
The purpose of this study is to evaluate the psychometric properties and utility of new, computerized, neurocognitive measures in humans with depression, and humans with depression undergoing electroc...
Eligibility Criteria
Inclusion
- Depressed Individuals
- Male and female subjects, age 18-85
- DSM-IV-TR diagnosis of major depressive episode, unipolar, confirmed by the MINI-PLUS \[221\]
- HRSD24 total score \> 10
- MMSE total score \> 26
- Graduated from high school
- Competent to provide informed consent
- Depressed Individuals Receiving ECT
- Same as for Depressed Cohort Inclusion Criteria (see above)
- Referred for ECT
- Subject competent to provide informed consent
- Individuals Diagnosed with PD
- Male and female subjects, age 18-85
- Diagnosed with PD
- MMSE total score \> 20
- Graduate high school
- Subject competent to provide informed consent
Exclusion
- Depressed Individuals/Depressed Individuals Receiving ECT
- Lifetime history of bipolar disorder, schizophrenia, schizoaffective disorder, or mental retardation
- Current neurostimulation treatment (e.g., ECT, MST, rTMS, vagus nerve stimulation, deep brain stimulation)
- Current alcohol abuse or dependence within past 12 months
- Current substance abuse or dependence within past 12 months
- Lifetime mental retardation
- History of central nervous system (CNS) disease
- Current diagnosis of dementia or delirium
- Current visual, auditory, or motor impairment that compromises ability to take tests
- Unable to read or comprehend English
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT01834677
Start Date
April 1 2013
End Date
November 1 2015
Last Update
December 3 2015
Active Locations (1)
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1
Duke Universtiy Medical Center
Durham, North Carolina, United States, 27710