Status:
COMPLETED
The Effects of Exercise in Parkinson's Disease
Lead Sponsor:
Pacific Parkinson's Research Centre
Conditions:
Parkinson Disease 10
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Parkinson's disease is caused by a reduction of dopamine causing motor deficits. The investigators are studying how exercise can help PD patients by increasing dopamine release in an area of the brain...
Detailed Description
The purpose of this study is to determine the basis for symptomatic and disease modifying benefits of exercise in Parkinson's disease (PD). Although the benefits of exercise in PD have been purported...
Eligibility Criteria
Inclusion
- Idiopathic PD according to UK Brain Bank criteria (modified to permit inclusion of subjects with a family history)
- Ages 40-70
- Mild to moderate Parkinsonism (Hoehn \& Yahr stages I-III)
Exclusion
- General exclusion criteria will include:
- more than 120 minutes per week of activities \>3 MET or a score exceeding 4 on the "Baseline Exercise Screening Tool" (Appendix, Fig. 1);
- atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.);
- significant osteoporosis or arthritis;
- other neurological disease (e.g. myopathy);
- self-reports claustrophobia;
- history of cancer within 5 years of study participation;
- high dose of radiation from other procedures within the year;
- taking rasagiline or selegiline for PD therapy;
- diabetic;
- not able to tolerate being off PD medication for up to 24 hours;
- BMI of 35 or more; and
- a female subject who is breast-feeding or pregnant.
- Exclusion criteria for MRI scanning and magnetic stimulation from rTMS scanning includes:
- artificial heart valve;
- brain aneurysm clip;
- electrical stimulator for nerves or bones;
- ear or eye implant;
- implanted drug infusion pump;
- coil, catheter, or filter in any blood vessel;
- orthopedic hardware (artificial joint, plate, screws);
- other metallic prostheses;
- shrapnel, bullets, or other metal fragments;
- surgery or tattoos (including tattooed eyeliner) in the last six weeks;
- have a cardiac pacemaker, wires or defibrillator;
- have had an injury where a piece of metal lodged in your eye or orbit;
- have a ferromagnetic aneurysm clip; and
- have a history of seizures.
- Subjects may be excluded following study enrollment if they meet any of the following exclusion criteria:
- significant cognitive impairment (Montreal Cognitive Assessment score \< 24) or depression (Beck Depression Inventory score \> 18);
- significant or unstable cardiovascular or respiratory disease - all subjects will undergo a screening exercise bicycle stress test; or
- failure to comply with the exercise or yoga/stretching intervention program, including missing 5 sessions or missing three sessions in a row.
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT01835652
Start Date
April 1 2013
End Date
March 1 2015
Last Update
March 17 2021
Active Locations (1)
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1
Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada, V6T 2B5