Status:
COMPLETED
Differential Effects of Ergocalciferol and Cholecalciferol Therapies in Chronic Kidney Disease
Lead Sponsor:
University of Kansas Medical Center
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study is to research two questions. First, is vitamin D3 more effective than vitamin D2 in raising 25-hydroxyvitamin D \[25(OH)D\] levels in chronic kidney disease (CKD) patients? And secondly, w...
Detailed Description
Vitamin D helps form and strengthens bones by allowing the body to absorb calcium. Vitamin D helps the immune system fight infection as well as helps keep muscles strong. Without enough vitamin D, bon...
Eligibility Criteria
Inclusion
- Age 18 and above
- Chronic kidney disease with an estimated glomerular filtration rate (GFR) between 15-60 ml/min (CKD stage III-IV)
- Vitamin D insufficiency (25-hydroxyvitamin D level \< 30 ng/mL) that has not been treated with vitamin D replacement since the acquisition of this level
Exclusion
- Current treatment with cholestyramine
- Presence of GI disorders such as short bowel, history of gastrectomy, colectomy, gastric bypass, inflammatory bowel disease, celiac disease, disorders of fat absorption, chronic diarrhea.
- Liver cirrhosis
- Known current substance abuse
- Current treatment with immunosuppressant medications
- Presence of chronic infection
- History of chronic inflammatory disease (i.e. - lupus, active rheumatoid arthritis, Crohns disease)
- Currently receiving high-dose vitamin D replacement (avg dose of ≥ 3,000 U per day) or "active" vitamin D analogue (e.g., calcitriol, which is 1,25-dihydroxyvitamin vitamin D).
Key Trial Info
Start Date :
October 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT01835691
Start Date
October 1 2011
End Date
June 1 2015
Last Update
October 19 2017
Active Locations (1)
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1
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160