Status:
UNKNOWN
Imaging of New Learning in Severe Alzheimer's Disease Patients
Lead Sponsor:
University Hospital, Caen
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
National Research Agency, France
Conditions:
Alzheimer Disease
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
This research attempts to better understand the altered and preserved memory mechanisms in Alzheimer disease, particularly to better apprehend learning implicit memory processes, and give a scientific...
Eligibility Criteria
Inclusion
- Native language: French
- Medical, neurological, neuropsychological and neuroradiological depth in accordance with the criteria for inclusion and exclusion-specific population, that is to say:
- Healthy Elderly volunteers: over 60 years old, living at home, without memory complaints, normal performances compared to the age and the educational level for all tests of the diagnostic battery.
- Alzheimer's patients: presenting the standard criteria of NINCDS-ADRDA probable Alzheimer's disease, including abnormal global cognitive function and deficits in at least two cognitive domains identified by the diagnostic battery.
Exclusion
- The sudden onset of cognitive impairments (as opposed to their slow and gradual installation in Alzheimer's disease)
- A chronic neurological, psychiatric, endocrine, hepatic or infectious complaint
- A history of major disease (an uncontrolled diabetes, a lung, heart, metabolic, hematologic, endocrine disease or a severe cancer);
- A medication that may interfere with memory or metabolic measures
- A alcohol or drugs abuse
- The cons-indications to MRI (claustrophobia, metallic object in the body).
- A predominantly left-hand (score below 50% in Edinburgh Inventory)
Key Trial Info
Start Date :
January 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT01839422
Start Date
January 1 2012
Last Update
April 9 2014
Active Locations (1)
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1
GIP Cyceron
Caen, France, 14000