Status:
TERMINATED
Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata
Lead Sponsor:
Centre Hospitalier Universitaire de Nice
Conditions:
Alopecia Areata
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
PHASE2
Brief Summary
Alopecia areata is an autoimmune disease associated with infiltration of cluster of differentiation 4(CD4 +) and cluster of differentiation 8 (CD8) + cells around the hair follicles. One of the therap...
Eligibility Criteria
Inclusion
- Age ≥ 18 years, 60 ≤ years.
- Male or female
- Clinical diagnosis of alopecia areata,
- Severe alopecia areata (\> 50% of the surface of the scalp reached)
- Alopecia areata resistant to at least one systemic therapy: phototherapy (UVB or PUVA), methotrexate or corticosteroids
- Signature of the informed consent and authorization of the right image
- Effective contraception will be maintained for the duration of the study.
- Affiliation to the Social Security
Exclusion
- Pregnancy or refusal of contraception in women of childbearing age,
- Refusal of contraception for men
- Local treatment (corticosteroids, minoxidil) or systemic (oral corticosteroids, methotrexate or other immunosuppressive agents) for less than 2 months,
- Cancer or autoimmune disease or in remission evolutionary
- Excessive alcohol intake (more than 3 glasses of wine a day or a drink per day)
- HIV, hepatitis C virus, hepatitis B virus
- Patient with renal and / or hepatic impairment,
- Patient with shingles, chickenpox, herpes, tuberculosis, an infectious disease scalable, respiratory failure ...
- Vulnerable person (anyone younger, adults under guardianship, deprived of liberty)
- Indication against treatment with IL2-R
- Presenting an indication against the Proleukin
Key Trial Info
Start Date :
November 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2013
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT01840046
Start Date
November 1 2012
End Date
May 1 2013
Last Update
August 31 2022
Active Locations (1)
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1
CHU de Nice - Hôpital Archet
Nice, Alpes-Maritimes, France, 06001